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Sarcasm is often used to express a negative opinion using positive here or intensified positive words in social media.This intentional ambiguity makes sarcasm detection, an important task of sentiment analysis.Sarcasm detection is considered a binary classification problem wherein both feature-rich traditional models and deep learning models have b
The complement is the first line of immune defense system involved in elimination of invading pathogens and dying host cells.Its activation is mainly triggered by immune complexes or pattern recognition molecules (PRMs) upon recognition against non-self or altered self-cells, such as C1q, collectins, ficolins, and properdin.Recent findings have int
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Endoplasmic reticulum-associated degradation (ERAD) is a protein quality control pathway of fundamental importance to cellular homeostasis.Although multiple ERAD pathways exist for targeting topologically distinct substrates, all pathways require substrate ubiquitination.Here, we characterize a key role for the UBE2G2 Binding Region (G2BR) of the E